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Thelmox 100 mg /kg, or a combination of baclofen and fluoxetine 20 g/kg (n=6);
2. Baclofen was evaluated in a double-blind, placebo-controlled study that investigated the impact of baclofen (6-month period) on behavior disturbances, depressive symptoms, and suicide attempts.
3. Baclofen was evaluated in a 3-week treatment trial and was found to be efficacious in the treatment of refractory depression in a randomized, double-blind, placebo controlled clinical trial for male adolescents.
4. Baclofen was found to be efficacious in a double-blind, 1-week placebo-controlled study in postmenopausal women with refractory or minimal estrogen therapy.
5. Baclofen was evaluated in a 4-week open-label double-blind, single-dose trial in men and women with mild to moderate anxiety, which included panic attacks, social anxiety, and generalized anxiety. The study was conducted in six hospitals and consisted of daily doses oral baclofen (400-800 mg daily) to 18 subjects and was performed after placebo treatment during week 2 of the treatment period.
6. Baclofen was found to be efficacious with a single dose in trial of 6 healthy volunteers with a severe migraine headache.
7. Baclofen was evaluated by investigators of a single dose study 10 healthy volunteers, which included a single dose of 20 mg/kg baclofen, and was found to be efficacious in the treatment of moderate postmenopausal women's symptoms including anxiety related to menopause.
8. Baclofen was evaluated by investigators of a single doses study 12 healthy persons. In the study, B. dithiolethin (Bd) was administered to 12 subjects, followed by Bd alone or with followed by Bg/d (N=8), Bd alone, and Bd, or placebo with without Bb (N=5).
9. Two double-blind, placebo-controlled investigations were carried out, one each, with 2 grams/kg in menopausal women with high or low serum lipids and one with 40 mg/kg/day, for 12 weeks, in patients with generalized anxiety disorder (GAD) in a randomized, double-blind, placebo-controlled clinical trial. Study of both studies failed to find statistically significant differences between the Bg and placebo groups in efficacy assessment measures and response rates.
10. Baclofen therapy was evaluated in three 8-week, placebo-controlled trials that evaluated its utility and safety as a treatment for patients at high risk developing neuroinflammation.
11. Two 8-week studies of 12 patients in bipolar disorder (BD) that had been previously treated for hypothyroidism failed to find an improvement in treatment response and quality of life when placebo was compared with a baclofen treatment regimen.
12. Baclofen treatment of patients with a subthreshold risk of developing post-traumatic stress disorder did not lead to improvements in neurocognitive performance or clinical mood.
13. Baclofen, given to healthy subjects, was assessed in a double-blind, placebo-controlled, cross-over study for two or three Adderal 90 $290.00 $3.22 $261.00 weeks. No differences were shown for mood and cognitive functioning. In 2 other trials of healthy subjects, no treatment effects were obtained. Bd alone or in combination with Bd and baclofen did not produce significant improvements.
Bd was evaluated by investigators in a single dose study conducted in patients with major depression, for 14 days (n=11, 2) in a randomized, double-blind, placebo-controlled study. No improvements were detected for any measure.
14. In a 1-week double-blind, placebo-controlled study with two grams/kg (n=16), Bd was added to pepsitol (50 mg) for 10 days. No effects were found on clinical variables of sleep, quality life or sleep EEG; and Bd did not enhance the effect of pepsitol. Bd was also evaluated by investigators in a 1-week study of healthy subjects (n=16), which employed a double blind, placebo-controlled cross-over design. No effects were seen on objective measures.
15. Bd (100 mg), given to healthy subjects, was investigated in two 6-month trials and an 8-week placebo controlled trial as well. No differences between Bd and placebo on a variety of outcomes could be observed. In contrast with the data on patients high or low serum cholesterol, no differences in the efficacy of Bd treatment were found in a study of normal weight men with elevated serum cholesterol (250-500 mg/day bw; n=13; p<0.05).
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